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   Requirements for compound submission


The CNCL demands that natural products and synthetic compounds coming into storage must have a defined structure, and not a duplicate with the existing compounds, with purities equal to or above 90%. They should also provide related spectra, e.g. LC/MS (MS and HPLC) and NMR, and meet screening requirements outlined below:

 

a. Compounds meeting screening requirements

 

General requirements: solid powder with molecular weight between 175 and 800

Heterocyclic and fused heterocyclic compounds

Saturated non-aromatic heterocycles with two or more substituted groups

Bridged bicyclic compounds: rings can be composed of the carbon atoms, two or three oxygen, sulfur or nitrogen atoms

Natural products and their derivatives: purified or synthesized
 

b. Compounds NOT meeting screening requirements
 

Liquids

Molecular weight less than 175 or over 800

Unstable or water/light-sensitive compounds

Polymers

Inorganic

Non-heteroatom compounds

Multi-core aromatic hydrocarbons

Organic compounds with heavy metals (Hg, Pb, As, Sn, Cr, etc.)

Oxygen-silane compounds

Hydrazones

Imines

Acridines

Pyridinium salts

Crown ethers

Phosphoryl halides

Trialkyl phosphates

Disulfides (non-ring)

Thioesters

Simple (thio) ureas (with molecular weight less than 350)

Perchlorate or periodate

Perchlorinated aromatic compounds

Epoxides

Acyl chlorides

Anhydrides

Iso (thio) cyanate esters (salt)

Active quinones

Azides, diazonium salts, azobenzenes

Hydrazines

N-oxide compounds

Nitroso compounds

N-halide compounds